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Are you a member of the 2am club?

We’ve crunched the numbers to reveal the hormone hour affecting many menopausal women’s sleep.

Are you a member of the 2am club?
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Does menopause affect sleep?

For many midlife women, sleep disturbances caused by hormonal changes are just one of the many signs of the menopause - one landmark study of over 4,000 women reported that 84% said they found sleeping one of the most difficult challenges during this stage of lifeAnxiety or depression - another sign of the menopause - was a struggle for 69% of women too, and both have been known to impact the quality of sleep. 

While research shows just how many people are experiencing the same sleep struggles, little is known about what timpeople are more susceptible to disturbed sleep and why.  

To help give women the tools to enjoy better nights and better days, we conducted our own research to find out when people are waking up the most. We also partnered with Dr Nikki Ramskill, women’s health GP and founder of The Female Health Doctor Clinic, for additional insights into the relationship between sleep and menopause  

Discovering the 2am ‘Hormone Hour’  

Over the course of one month, we analysed daily Google Trends data to identify patterns around people’s search habits for terms related to sleep and the signs of menopause. Each day, from the hours of 9.00pm – 7.00am, we looked at searcinterest valuefor the search terms: night sweats’, ‘menopause’ and ‘perimenopause’, ‘tired’, ‘can’t sleep’, ‘stress’, ‘anxiety’ and ‘insomnia’. 

The figures provide relative interest signals that signify a measure of popularity for each search term, with data displayed in time increments and a scale of 1-100, with 100 showing the highest search interest. The figures were then added up across the four-week period to create total figures for each search term. 

Although the search data is gathered from people of all ages and genders across the UK, the specific search terms analysed can give an indication into the sleep struggles experienced by midlife women across the country. 

When combining data from all the search terms we analysed over the course of four weeks, 2am-3am was the most active nighttime searching hour. On three out of the four weeks, this time slot was when the highest volume of all monitored search terms took place during the night 

If you’re one of the many people up at 2am, struggling to sleep and wondering if your hormonal shifts are to blame, this suggests that there may be lots more people in the same boat.

The 2am club, explained 

Dr Nikki Ramskill said that the 2am findings mirrored what women tell her in her clinic every day, as well as her own experiences.  

She explains: There probably isn't one single biological event that happens at exactly 2am, but there are several reasons this can become a particularly difficult time of night.

During the second half of the night our sleep naturally becomes lighter, so we're more easily woken by things like a night sweat, needing the toilet or even a small disturbance. For women experiencing night sweats, even a slight rise in body temperature can be enough to trigger an awakening. Many women also describe waking with a racing mind. There isn't strong evidence that our worries become objectively worse at 2am, but when the world is quiet and there are no daytime distractions, anxious thoughts can feel much louder.   

If sleep has already been fragmented by hot flushes, stress or anxiety, that normal physiological rise may make it harder to drift back to sleep. So rather than there being a single '2am hormone', it's more likely that several normal physiological processes combine with menopausal changes, making this one of the most vulnerable times of the night for waking.

Crunching the data

Looking closer into each specific search term offered some additional interesting insight into people’s early morning search habits.  

The search termenopause’ had the fourth highest search volume of all terms that were monitored across the four-week study period, and 5am - 6am was when people searched for it most. This is when ‘night sweats’ was also searched for most, and while the term had the lowest relative search volume across all terms monitored due to its niche nature, looking at when it was Googled does showcase a pattern for those going through midlife hormonal changes. 

Anxiety had the highest relative search volume overall across the four weeks of the study, with 2am – 3am being the time slot when it was most commonly searched for. This was followed by ‘stress’, which was searched for at different times during the four-week study, while ‘can’t sleep’ had the least search volume overall 

I think this makes a lot of sense. For many women this is the moment they realise they probably aren't going to get back to sleep, so they reach for their phone looking for answers. By 5am or 6am, many women have already experienced several hours of broken sleep. They've perhaps woken multiple times because of heat, sweating, anxiety or needing the toilet, and they're exhausted.  

This is also the point where the body's natural circadian rhythm is preparing us to wake. Cortisol levels are rising, body temperature regulation is changing and sleep becomes even lighter. This can worsen hot flushes, which in turn can raise cortisol levels. It's a vicious cycle.   

As doctors we often see that search for answers happening long before women seek medical advice. They're trying to work out whether what they're experiencing is normal, whether it's menopause, and whether anyone else feels the same way before "bothering" their doctor. Of course, you're not bothering us - we want to help you feel better.

“Cortisol shouldn’t be forgotten about for the role it could play in sleep disruption. While it's not a menopause hormone, stress hormones often become much more noticeable during this stage of life. Many women are juggling careers, ageing parents, teenage children and their own health, and chronic stress can significantly worsen sleep disruption.”

The science behind sleep disturbances

According to Dr Nikki, one of the biggest misconceptions about menopause is that sleep problems are simply caused by hot flushes. While signs like hot flushes certainly play a role, the reality is much more complex.

Dr Nikki said: “During perimenopause, oestrogen and progesterone fluctuate significantly before eventually declining. Progesterone starts declining first, followed by oestrogen. These hormones influence far more than our reproductive system. They affect the brain, nervous system, temperature regulation, mood, the different stages of sleep we go through in the night, and our response to stress. 

One of the most important areas involved is a brain structure called the hypothalamus, which acts as the body's thermostat. As oestrogen levels fluctuate, the hypothalamus becomes much more sensitive, narrowing what we call the thermoneutral zone’. That means even tiny changes in core body temperature can trigger the body's cooling response, resulting in a sudden hot flush or night sweat that wakes a woman from deep sleep. 

We're also learning more about the role of neurokinin B, a brain signalling molecule that becomes more active when oestrogen levels fall. This appears to play a key role in triggering vasomotor symptoms such as hot flushes and night sweats. At the same time, falling progesterone can reduce some of the calming effects many women previously experienced, leaving them feeling more restless or wired but tired’. 

Sleep is also influenced by neurotransmitters such as serotonin and GABA (gamma-aminobutyric acid), both of which are affected by hormonal change. This helps explain why sleep disruption, anxiety, mood changes and brain fog often occur together rather than as isolated symptoms. As a result, many women don't simply struggle to fall asleep, they can wake repeatedly throughout the night and often feel as though they haven't slept at all.

The hormonal change that could be the cause of waking at night

Dr Nikki explained that it’s rarely one hormone acting alone, and instead a “perfect storm” could be caused by an interaction between changing reproductive hormones, stress hormones and the body’s internal clock. 

“Oestrogen is probably the biggest player because it influences temperature regulation, serotonin pathways, mood, blood vessels and sleep quality.  

“Progesterone is also highly important because it has naturally calming effects on the brain. As progesterone levels fluctuate and decline, some women feel noticeably more anxious, restless or unable to switch off. This is the reason why women should have a proper discussion about the types of hormone replacement therapies they use during perimenopause and beyond, so that sleep disturbances are taken into consideration. Many progesterone drugs are actually synthetic progestins which don't have the same helpful benefits for sleep.  

“Melatonin, the hormone that helps regulate our sleep-wake cycle, naturally declines with age too, which may also contribute to poorer quality sleep. 

She noted how sleep disturbances are one of the most common signs of menopause women describe when coming to her clinic, yet is rarely the reason for making the appointment. 

She said: “Instead they come because they're exhausted, anxious, gaining weight, struggling with brain fog or feeling like they're no longer themselves.  

“When we explore things further, many reveal they've been waking up in the night regularly for months or even years.  

“The other challenge is that women often normalise poor sleep. They'll tell me that they thought it was just stress, or due to getting older. But sleep problems shouldn't simply be accepted as an inevitable part of ageing. They're common, but they're also treatable. 

“However, it's worth remembering that not every woman who wakes in the early hours is experiencing menopause, and not every sleep problem during menopause is caused by hormones. That's why taking a proper medical history is so important. 

If you’re going through the menopause and waking up at night, here’s what to do 

Dr Nikki Ramskill shared six tips for women to follow if they’re struggling with sleep during the menopause and perimenopause.


1.

Limit alcohol in the evening, as it can worsen hot flushes and fragment your normal sleep cycle, reducing the quality of sleep.  


2.

Avoid caffeine after midday if you're becoming more sensitive to it and look for other natural alternatives to support energy.


3.

Eat balanced meals with plenty of proteintryptophan and slow-acting carbohydrates to help support stable blood sugar. Helpful foods include chicken, fish, eggs,edamame beans, tofu, quinoa and pumpkin seeds.  


4.

Exercise regularly during the day, as movement is one of the best ways to improve sleep quality. Try not to exercise immediately before sleep though 


5.

Speak to a healthcare professional. Don't assume you simply have to put up with it. Treatments such as Hormone Replacement Therapy can be incredibly effective for women whose sleep disruption is being driven by menopause. 


6.

Create a consistent bedtime routine that helps your brain wind down, and maintain a consistent wake up time, even on weekends.  

84%

of women found sleeping one of the most difficult challenges during this stage of life

69%

of women struggle with anxiety or depressing during midlife

27%

of women are managing symptoms with supplements

Avoiding a ‘sleep hangover’ the day after a disturbed night’s sleep.

“The biggest thing is not to panic.” says Dr Nikki. “One bad night's sleep doesn't undo your health, and worrying about it often makes the following night worse.  

“Get outside into natural daylight as early as possible, stay hydrated, eat regular protein-rich meals and move your body, even if it's just a gentle walk.  

“Try not to compensate with excessive caffeine or sugary foods, as these can cause an energy crash later in the day. If you need a nap, keep it short, around 20 minutes, and avoid sleeping late into the afternoon. 

“Finally, be kind to yourself. If you've had a terrible night's sleep, today probably isn't the day to expect peak performance. Adjust your expectations where you can and prioritise recovery.” 

In additionmany women my find that supplements can offer much-needed helping hand. In fact, our recent research found that 27% of women are currently using supplements to manage their experiences with the signs of perimenopause, menopause and post-menopause. 

When Serenova launched back in 2025, it launched with a mission to empower women to navigate what is a highly complex stage of lifeMillions of women across the world are silently battling one or more signs of menopause and sleep is such an important part of life.

Our Rest & Renew and Balance & Boost science-backed supplements have been created to enrich women’s evening routines and empower their days. 

Res& Renew is designed to supporrestful sleep. With more than 250mg of magnesium per serving and glycine – a naturally occurring amnio acid  each sachet combines carefully selected ingredients traditionally used to promote relaxation so women can wake feeling refreshed and restored. 

To help support better days, even after a disturbed night of sleepBalance & Boost has been carefully blended to nourish and support the body’s natural rhythm, helping women take charge of their daysEach sachet combines lion's mane mushroom, ashwagandha, green tea and maca root to support energy, focus and overall wellbeing, creating a solid foundation for a better day ahead.  

Dr Nikki says:

“Sleep is one of the foundations of good health, so when it suffers, almost everything else becomes harder. Poor sleep affects the brain's ability to regulate emotions, process memories and concentrate. That's why women often describe feeling more forgetful, more irritable and less able to cope after a series of bad nights. 

“One of the things I often tell patients is that poor sleep doesn't just make you tired, it amplifies almost every sign of menopause.” 

“Don't suffer in silence because you think it's "just part of getting older." I meet so many women who've accepted years of poor sleep because they've been told it's normal or that they simply have to put up with it. 

Poor sleep deserves to be taken seriously. It can affect physical health, mental health, relationships, work performance and overall quality of life. There are effective treatments available, and no woman should feel she has to struggle alone.”

Are you in the 2am club? Join our Better Nights community 

If you find yourself waking at the early hours of the morning, just know you’re not alone. Our research has helped show that there are so many other people who share your sleep struggles. 

We’re inviting women who have difficulties sleeping to join our Better Nights Community where we’re encouraging people to take part in our 7-day reset. As part of the community, for one week you’ll receivdedicated tips and advice from our expertsdirect to your inbox 

To sign up, simply enter your email address here, and let us help you reap the benefits of better nights and better daysWe’ve also launched a neInstagram broadcast channel over on @serenovanutrition, where we’ll be sharinfurther insights as well as messages of motivation and you’ll have the opportunity to connect with others whmay find themselves members of the 2am can’t sleep club too. Feel free to give us a follow and join the club. 

To help you on your journey to a morrestorative night of sleepwe’re offering a free 7-day trial of our MTick-certified Rest & Renew. Get yours here.  

Methodology 

For four weekseight keywords were monitored using Google Trends to understand how popular each search term was relatively, and at what time people were likely to search for each oneData was downloaded every day and was split out into one hour time slots so that daily search interest could be understood. Search interest for each keyword was logged during ‘bedtime hours’ of 9pm to 7am each day only.  

The keywords that were monitored were chosen for their link to the signs of menopause. Although the Google Trends search data is gathered from people of all ages and genders across the UK, the search terms analysed can give an indication into the sleep struggles experienced by midlife women across the country. 

The data given by Google Trends reflects how many searches have been done for the particular term relative to the number of searches done on Google.